Our research, published in 2020 in Viruses (MDPI), titled ‘Comprehensive Evaluation of the Safety and Efficacy of BAFASAL® Bacteriophage Preparation for the Reduction of Salmonella in the Food Chain’, has gained renewed significance.
European Food Safety Authority (EFSA) has recently published another positive scientific opinion confirming BAFASAL®’s potential. This validation supports our findings on BAFASAL®’s effectiveness as a zootechnical additive in reducing Salmonella Enteritidis contamination in poultry production environments.
We invite you to explore the research methodology, study design, and key findings that are helping shape the future of food safety.
To read the full article, click here.
Introduction: Salmonella contamination in poultry feed is a major challenge for food safety and public health. The use of bacteriophages, which are viruses that specifically target bacteria, represents a promising strategy to mitigate this issue.
Objective: The primary objective of this study was to comprehensively assess the safety and efficacy of BAFASAL® in reducing Salmonella contamination in poultry feed, thereby reinforcing its significance in enhancing food safety within the poultry production chain.
Methodology: The research involved a series of experiments conducted under Good Laboratory Practice (GLP) and OECD guidelines (OECD Environment, Health and Safety Publications).
Key aspects:
- Toxicity Studies: Animals like rats and chickens were tested to ensure that BAFASAL® is non-toxic and safe.
- In Vitro Studies: BAFASAL®’s effectiveness was tested on Salmonella contaminated feed, in a simulated crop environment. The preparation was applied in different forms (liquid, powder, spray) in different feed types (solid and supplemental liquid).
- In Vivo Studies: The effectiveness of BAFASAL® was evaluated by measuring Salmonella levels in the digestive systems of chickens.
Results:
- BAFASAL® effectively reduced Salmonella levels by over 99% in treated feed samples.
- No signs of toxicity or genotoxicity were observed during the animal studies, confirming the safety profile of BAFASAL®.
- BAFASAL® remained effective even after being stored under different temperature conditions.
The conclusion: This study confirms the potential of BAFASAL® as a safe and effective solution for reducing Salmonella contamination in poultry feed. Its use could improve food safety, reduce the risk of antimicrobial resistance, and support more sustainable farming practices.
Authors: Ewelina A. Wójcik, Małgorzata Stańczyk, Arkadiusz Wojtasik, Justyna D. Kowalska, Magdalena Nowakowska, Magdalena Łukasiak, Milena Bartnicka, Joanna Kazimierczak, and Jarosław Dastych.
Proteon Pharmaceuticals is at the forefront of bacteriophage technology, focusing on advancing livestock farming and aquaculture. Our mission is to reduce antimicrobial resistance (AMR) and promote sustainable protein production. By harnessing cutting-edge technologies like molecular biology, bioinformatics, and artificial intelligence, we develop precise phage-based solutions that enhance animal health and welfare.
